All forms of NF cause patients to develop benign (non-metastatic) tumors along their nerves. The hallmark symptom of NF1 is the appearance of these tumors on the skin.
Approximately half of people with NF1 will develop plexiform neurofibromas. These tumors are disfiguring and can interfere with the function of internal organs.
Optic gliomas form in a quarter of patients with NF1. There are many additional symptoms of this disease which adversely effect patients and their families.
Patients with NF2 develop schwannomas in their central nervous system. These tumors can cause deafness and interfere with the normal functioning of the brain.
Schwannomatosis causes tumors to appear along peripheral nerves. These tumors can be painful and interfere with the normal function of the surrounding tissue.
If one parent has NF then, on average, half of their children will have the disease. Children may exhibit completely different symptoms from their parents.
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